쥐의 골세포에서 PGE2 합성과 plasminogen activator 활성 조절에 의한 IL-1■의 골 흡수유도와 TGF-■에 의한 골 흡수 억제 기전에 관한 연구
Interleuken-1 ■ induces bone resorption by regulation of prostaglandin E2 synthesis and plasminogen activator activity, and TGF-■ inhibits bone resorption of rat bone cells
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김영훈
KMID : 0361920000300060713
Abstract
Bone cells produce multiple growth factors and cytokines that have effects on bone metabolism and can be incorporated into the bone matrix. The present study was designed to extend these observations by examining the interactions between transforming growth factor-Il (TGF-p) or interleukin-1)3 (rh1L-111) and bone cells in a rat long bone culture model. IL-1)3 regulates several activities of the osteoblast cells derived from rat long bone explants in vitro. IL-113 stimulated cellular proliferation as well as the synthesis of prostaglandin E2 and plasminogen .activator activity in the cultured cells in a dose-dependent manner. TGF-D is present in the bone matrix and potentially released during bone resorption. TGF-l3 reduced basal bone resorption and inhibited vitamin 1)3 [1,2b(OH)2D31-induced bone resorption in rat long bone cells. These results support the role.of IL-ill in the pathological modulation of bone cell metabolism, with regard to implication in the pathogenesis of osteoporosis by IL-1p, and that TGF-i3 positively inhibits the bone resorptio~L
키워드
Interleukin 1-β;Tranforming Growth Factor-β;osteoblast;osteoclast;Prostaglandin E_(2);Plasminogen activator;bone resorption;IL-1β;TGF-β;조골세포;피골세포 PGE_(2);골흡수
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